Grant Road between Palo Verde Road and Dodge Boulevard is closed due to a crash involving an armored truck, a van and a power pole.
Two people were injured, one has life-threatening injuries, said Capt. Barrett Baker, a Tucson fire spokesman.
The armored truck hit a power pole and crews from Tucson Electric Power are on the scene, Baker said.
Tucson police are helping direct traffic.
No other information was immediately available.